Sunovion, PsychoGenics nondopamine schizophrenia drug meets phase 2 endpoint

Sunovion Pharmaceuticals and PsychoGenics unveiled constructive phase 2 outcomes for a brand new schizophrenia therapy that doesn’t bind to the mind’s dopamine receptors.

While its precise mechanism of motion is unknown, the 2 firms imagine that SEP-363856 prompts hint amine-associated receptor 1 (TAAR1) along with the serotonin receptor 5-HT1A with out binding to different serotonergic receptors.

TAAR1 helps regulate dopamine, norepinephrine and serotonin transmission, and has results within the mind’s immune system. Direct activation of dopamine and serotonin receptors, in the meantime, is believed to mediate the results of present antipsychotic medicine, which for many years have centered on blocking dopamine receptors, the businesses mentioned.


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The placebo-controlled research met its major endpoint, enrolling 245 hospitalized sufferers with acute worsening of schizophrenia and demonstrating enhancements in a complete syndrome scale over 4 weeks of daily therapy. Improvements had been additionally seen within the general severity of sickness and psychopathology subscales.

“The results of this first placebo-controlled study assessing the utility of SEP-363856 in patients with schizophrenia are exciting, and we intend to advance the development of this novel investigational medicine as quickly as possible,” said Sunovion Chief Medical Officer Antony Loebel, who additionally heads international medical growth for Sumitomo Dainippon Pharma Group. The research’s outcomes had been introduced at annual assembly of the American College of Neuropsychopharmacology.

SEP-363856 was recognized via a collaboration using PsychoGenics’ SmartCube neurological drug discovery platform, via a mechanism-independent strategy.

The in vivo SmartCube platform pits handled mice in opposition to a sequence of challenges, whereas capturing bioinformatics and behavioral profiles to investigate the potential of various compounds to deal with psychiatric problems.

The drug, which can also be being studied in Parkinson’s illness psychosis, is collectively owned by Sunovion and PsychoGenics, with Sunovion holding unique rights to international growth and commercialization.

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