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Pasithea Therapeutics: A High-Potential Biopharma

  • The market is betting on ketamine’s exciting potential as a market-leading antidepressant and treatment for other treatment-resistant psychiatric disorders. It is also betting on its CEO and Chairman, two renowned authorities in their respective fields.
  • The company is brand new and pre-revenue
  • We believe in the company leadership and the potential for ketamine to transform how we approach mental health treatment. While this is an early-stage investment  KTTA could take off if it can develop new drugs and expand their clinics in the US and UK markets.

Pasithea Therapeutics has recently gone public with some lofty goals. It wants to become the leader in ketamine administration services in the US and the UK. It is first and foremost betting on ketamine’s potential as a novel treatment approach in psychiatry, a prospect that looks likely given the early data that ketamine have a far better risk and efficacy profile than drugs currently on the market for Major Depressive Disorder and other diseases.

From there, the company has much a much higher aim: to develop its own novel treatments for CNS disorders, leveraging its leaders’ unique insight into how the brain and the immune system influence these conditions. While the company’s tomorrow will rely on invention, the present is built on reinventing a known (and misunderstood) drug.

The Power of Ketamine:

Some know of ketamine as an effective anesthetic, a use for which the  FDA has granted approval. Others know it as “Special K”, a party drug that causes a psychotropic experience. Few know of the drug as a groundbreaking treatment for depression and other psychiatric disorders. That could change in the years to come.

Ketamine joins other drugs, such as psychedelics, as substances with major healing potential but a powerful stigma, due to its recreational use. This stigma not only color’s public opinion, but can create roadblocks to its treatment potential. However, while psychadelics are still not available for medical purpose, ketamine is FDA-approved and has showed robust results  to treat mental disorders.

A growing body of evidence shows that ketmaine can drastically mitigate mental disorders, notably Major Depressive Disorder (MDD). In the company filings, Pasithea cites a double-blind study that found current treatments to be only as high as 50% effective in treating MDD patients. When these treatments are effective, they can take weeks to take any effect, which can be highly stressful for patients and make it difficult for doctors to decide whether to continue or change medications. Furthermore, up to 30% of patients with antidepressants did not respond to antidepressant medication and therefore are considered to have treatment-resistant depression.

Ketamine shows promise as a better way forward. Administering sub-anesthetic levels of the drug have been shown in clinical studies to be up to 70% effective in improving symptoms of patients with treatment-resistant MDD, sometimes even after a single dose. It has shown to be effective for other mental health disorders, such as the treatment resistant post-traumatic stress disorder (PTSD) or bipolar depression. The United States and the much of the developed world has seen soaring rates of mental and other nervous system disorders.  In as little as one dose, Ketamine may give what many patients have struggled to find for years: relief.

Just the First Step

Ketamine is the main revenue and publicity driver in the near term, but the company has no intention of staying solely in this space for long. Her primary focus in on developing new drugs for the treatment of psychiatric and neurological disorders.   

In developing its own treatments for CNS disorders, the company plans to move forward a drug development campaign with the objective to develop up to 3 new drug candidates. The idea is to bring totally new treatment options to a high-demand market, establishing the company as a leader in innovative care for brain disorders.

The company is placing its trust in two highly regarded leaders in the field: Professor Lawrence Steinman and Dr. Tiago Reis Marques. Prof Steinman is a world-renowned neurologist and neuroscientist based in Stanford University, and will serve as Chairman of the Board of Directors. The company’s CEO is Dr. Tiago Reis Marques, an academic psychiatrist at King’s College and Imperial College in London. Both leaders are at the pinnacle of their fields, and lend much-needed credence to the company’s  ambitions and scientific leadership.

The company’s mission is to use capital from its ketamine operations to support the drug development campaign, leveraging the immense knowledge of its Chairman and CEO in the field of pharmaceuticals, neurology and immunology. They seek to better understand, and treat, the mysterious and often problematic relationship between the brain and the immune system, which they believe is a major player in these conditions.

The leaders’ simple ability to raise so much money for this venture, even going public at such an early stage, speaks to industry confidence in both men, as well as confidence that ketamine will indeed play a role in treating several psychiatric disorders. 

The Road to Revenues

Pasithea is priced to recognize the long, uncertain road to a potential fortune. In exploring novel treatments for CNS disorders, there are a lot of hurdles before the company can, like other major pharmaceutical firms, become a high-margin cash cow. As Pasithea itself states, this future is more than two years out. 

Drug pipelines are notoriously long and hard, and Pasithea Therapeutics is starting from scratch. The company will face a challenging task in achieving its main goal: developing novel drugs for CNS illnesses. However, these costs can be offset by the revenues generated by their clinics, as doctors can and already prescribe ketamine for psychiatric purposes, such as to treat Major Depressive Disorder.

However, with their therapy clinics coming online, near-term revenues will not be far behind.

Current Financials

KTTA’s financials reflect its early-stage pre revenue status. The firm went from inception to IPO in one and  a half year, and incurred a loss of $1.3 million for the period ended June 30, as it started the drug development program and stablishes its first clinics . The second half of the year should see similar losses, although the company expects to see revenue from its ketamine operations in Q4.

It’s important to reiterate that the fact the company’s IPO and $35 million valuation at this very early stage speaks loudly to industry insiders’ belief not only in ketamine’s latent potential, but the men who lead the Pasithea Therapeutics. It cannot be overstated the respect that Dr. Steinman and Dr. Marques garner in their fields.

Final Thoughts

Pasithea Therapeutics is offering transformational treatments to a multi-billion dollar industry. Its run by two world-renowned leaders, both of whom have a track record of advancing the science of this industry, are aiming high. From bringing ketamine from the operating room to outpatient CNS treatments, to developing novel drugs to tackle the world’s most vexing illnesses, this company is driven by brilliant men who think big and look for new solutions. While they wont make a million dollars this year, we believer that the industry will gravitate toward the Pasithea Theraputics treatment offerings in the near term, once the clincs are up and running. A bet on KTTA is a bet on those two minds, as well as the mounting evidence that ketamine can be a tremendous treatment for a number of ailments in the future.


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